The Asia-Pacific Alliance for the Control of Influenza (and other respiratory diseases) was established as a charitable institution in April 2011.

It has an independent Board of Directors, and a membership consisting of individuals with a recognised expertise in influenza. APACI is a company limited by guarantee, with its registered office in Hong Kong, and its operational office in Melbourne, Australia.

APACI was previously known as the Asia-Pacific Advisory Committee on Influenza, having been established in early 2002. It has been active in the region since that time, but has moved beyond a committee, to an alliance of Asian-Pacific countries.